Travel Health Advisory

All eligible travelers should be up to date with their COVID-19 vaccines. Please seeYour COVID-19 Vaccinationfor more information.

All travelers should take steps to prevent mosquito bites. Chikungunya vaccination is generally not recommended. Travelers who wish to consider vaccination can visit “What to consider before traveling” on thechikungunya vaccinespage to learn more.

Recommended for unvaccinated travelers one year old or older going to Nicaragua.Infants 6 to 11 months old should also be vaccinated against Hepatitis A. The dose does not count toward the routine 2-dose series.Travelers allergic to a vaccine component should receive a single dose of immune globulin, which provides effective protection for up to 2 months depending on dosage given.Unvaccinated travelers who are over 40 years old, are immunocompromised, or have chronic medical conditions planning to depart to a risk area in less than 2 weeks should get the initial dose of vaccine and at the same appointment receive immune globulin.

Recommended for unvaccinated travelers younger than 60 years old traveling to Nicaragua. Unvaccinated travelers 60 years and older may get vaccinated before traveling to Nicaragua.

CDC recommends that travelers going to certain areas of Nicaragua take prescription medicine to prevent malaria. Depending on the medicine you take, you will need to start taking this medicine multiple days before your trip, as well as during and after your trip. Talk to your doctor about which malaria medication you should take.Transmission areasRegión Autónoma Atlántico Norte (RAAN) and Región Autónoma Atlántico Sur (RAAS)Rare cases in the departments of Boaco, Chinandega, Estelí, Jinotega, León, Matagalpa, Nueva Segovia, and other parts of the countryNo malaria transmission in Managua (the capital)Drug resistanceNoneSpeciesP. vivax(80%)P. falciparum(20%)Recommended chemoprophylaxisRegión Autónoma Atlántico Norte (RAAN) and Región Autónoma Atlántico Sur (RAAS): Atovaquone-proguanil, chloroquine, doxycycline, mefloquine, tafenoquine2All other areas with malaria transmission: No chemoprophylaxis recommended (insect bite precautions and mosquito avoidance only)4Updated April 23, 2025See footnotes

Cases of measles are on the rise worldwide. Travelers are at risk of measles if they have not been fully vaccinated at least two weeks prior to departure, or have not had measles in the past, and travel internationally to areas where measles is spreading.All international travelers should be fully vaccinated against measles with the measles-mumps-rubella (MMR) vaccine, including an early dose for infants 6–11 months, according toCDC’s measles vaccination recommendations for international travel.

Dogs infected with rabies are sometimes found in Nicaragua.Rabies is also present in bats.If rabies exposures occur while in Nicaragua, rabies vaccines may only be available in larger suburban/urban medical facilities.Rabies pre-exposure vaccination considerations include whether travelers 1) will be performing occupational or recreational activities that increase risk for exposure to potentially rabid animals and 2) might have difficulty getting prompt access to safe post-exposure prophylaxis.Please consult with a healthcare provider to determine whether you should receive pre-exposure vaccination before travel.For more information, seecountry rabies status assessments.

Recommended for most travelers, especially those staying with friends or relatives or visiting smaller cities or rural areas.